USA: Miami - Singles - Main |
| 1/16-finals | Opelka R. | Machac T. | 0:2 (61:7, 3:6) | detalhes | 24.03.2025 |
| 1/32-finals | Rune H. | Opelka R. | 1:2 (6:4, 3:6, 65:7) | detalhes | 22.03.2025 |
| 1/64-finals | Eubanks C. | Opelka R. | 0:2 (3:6, 64:7) | detalhes | 20.03.2025 |
USA: Phoenix - Singles - Main |
| 1/8-finals | Opelka R. | Gaston H. | 0:2 (66:7, 3:6) | detalhes | 13.03.2025 |
| 1/16-finals | Rinderknech A. | Opelka R. | 1:2 (6:4, 5:7, 5:7) | detalhes | 12.03.2025 |
USA: Indian Wells - Singles - Main |
| 1/64-finals | Safiullin R. | Opelka R. | 2:0 (7:5, 6:4) | detalhes | 05.03.2025 |
USA: Delray Beach - Singles - Main |
| 1/8-finals | Opelka R. | Nakashima B. | 1:2 (6:3, 5:7, 2:6) | detalhes | 13.02.2025 |
| 1/16-finals | Eubanks C. | Opelka R. | 0:2 (3:6, 67:7) | detalhes | 12.02.2025 |
USA: Dallas - Singles - Main |
| Quarter-finals | Paul T. | Opelka R. | 2:0 (7:63, 6:2) | detalhes | 08.02.2025 |
| 1/8-finals | Opelka R. | Norrie C. | 2:1 (4:6, 7:65, 6:4) | detalhes | 06.02.2025 |
| 1/16-finals | Opelka R. | Shevchenko A. | 2:0 (7:63, 6:4) | detalhes | 05.02.2025 |
Australia: Australian Open - Singles - Main |
| 1/32-finals | Opelka R. | Machac T. | 2:3 (6:3, 61:7, 7:65, 64:7, 4:6) | detalhes | 15.01.2025 |
| 1/64-finals | Onclin G. | Opelka R. | 1:3 (6:3, 64:7, 3:6, 2:6) | detalhes | 12.01.2025 |
New Zealand: Auckland - Singles - Main |
| 1/16-finals | Navone M. | Opelka R. | CAN. | detalhes | 06.01.2025 |
Australia: Brisbane - Singles - Main |
| Final | Opelka R. | Lehecka J. | 0:0 RET. (1:4) | detalhes | 05.01.2025 |
| Semi-finals | Opelka R. | Mpetshi Perricard G. | 2:0 (6:3, 7:64) | detalhes | 04.01.2025 |
| Quarter-finals | Djokovic N. | Opelka R. | 0:2 (66:7, 3:6) | detalhes | 03.01.2025 |
| 1/8-finals | Opelka R. | Arnaldi M. | 2:0 (7:69, 7:64) | detalhes | 02.01.2025 |
| 1/16-finals | Gomez F. A. | Opelka R. | 0:2 (5:7, 4:6) | detalhes | 31.12.2024 |
USA: Charlottesville - Singles - Main |
| 1/8-finals | Opelka R. | Smith C. | 1:2 (7:65, 4:6, 4:6) | detalhes | 30.10.2024 |
| 1/16-finals | Popko D. | Opelka R. | 1:2 (7:5, 1:6, 61:7) | detalhes | 28.10.2024 |
China: Shanghai - Singles - Main |
| 1/64-finals | Opelka R. | Rinderknech A. | 0:2 (4:6, 65:7) | detalhes | 02.10.2024 |
Japan: Tokyo - Singles - Main |
| 1/16-finals | Opelka R. | Shelton B. | 1:2 (6:3, 1:6, 4:6) | detalhes | 26.09.2024 |
China: Hangzhou - Singles - Qualification |
| Semi-finals | Opelka R. | Yevseyev D. | 1:2 (64:7, 6:4, 3:6) | detalhes | 17.09.2024 |
World: Davis Cup - World Group - Singles - Main |
| | Squire H. | Opelka R. | 1:2 (7:64, 69:7, 3:6) | detalhes | 14.09.2024 |
| | Opelka R. | Garin C. | 2:1 (6:3, 4:6, 7:63) | detalhes | 11.09.2024 |
USA: US Open - Singles - Main |
| 1/64-finals | Opelka R. | Musetti L. | 1:3 (63:7, 6:1, 1:6, 5:7) | detalhes | 26.08.2024 |
USA: Winston-Salem - Singles - Main |
| 1/32-finals | Bergs Z. | Opelka R. | 2:1 (6:4, 3:6, 7:61) | detalhes | 18.08.2024 |
USA: Cincinnati - Singles - Main |
| 1/32-finals | Shelton B. | Opelka R. | 2:0 (7:63, 7:63) | detalhes | 13.08.2024 |
USA: Washington - Singles - Main |
| 1/16-finals | Opelka R. | Thompson J. | 0:2 (4:6, 3:6) | detalhes | 01.08.2024 |
| 1/32-finals | Opelka R. | Duckworth J. | 2:1 (612:7, 7:5, 6:4) | detalhes | 30.07.2024 |
USA: Atlanta - Singles - Main |
| 1/8-finals | Opelka R. | Davidovich Fokina A. | 0:2 (5:7, 5:7) | detalhes | 25.07.2024 |
| 1/16-finals | Opelka R. | Kovacevic A. | 2:0 (6:3, 7:65) | detalhes | 24.07.2024 |
USA: Newport - Singles - Main |
| Semi-finals | Opelka R. | Michelsen A. | 0:2 (2:6, 0:6) | detalhes | 20.07.2024 |
| Quarter-finals | Opelka R. | McDonald M. | 2:1 (4:6, 6:3, 6:4) | detalhes | 18.07.2024 |
| 1/8-finals | Mannarino A. | Opelka R. | 1:2 (4:6, 6:3, 4:6) | detalhes | 17.07.2024 |
| 1/16-finals | Lestienne C. | Opelka R. | 1:2 (1:6, 6:2, 62:7) | detalhes | 15.07.2024 |
USA: Charlottesville - Singles - Main |
| 1/8-finals | Mayo A. | Opelka R. | WO. | detalhes | 02.11.2023 |
| 1/16-finals | Opelka R. | Sandgren T. | 2:0 (6:4, 7:5) | detalhes | 01.11.2023 |
Canada: Montreal - Singles - Main |
| 1/32-finals | Opelka R. | Monfils G. | CAN. | detalhes | 08.08.2022 |
USA: Washington - Singles - Main |
| 1/8-finals | Kyrgios N. | Opelka R. | 2:0 (7:61, 6:2) | detalhes | 05.08.2022 |
| 1/16-finals | Kudla D. | Opelka R. | 1:2 (7:66, 4:6, 4:6) | detalhes | 04.08.2022 |
USA: Atlanta - Singles - Main |
| 1/8-finals | Opelka R. | Ivashka I. | CAN. | detalhes | 28.07.2022 |
United Kingdom: Wimbledon - Singles - Main |
| 1/32-finals | van Rijthoven T. | Opelka R. | 3:1 (6:4, 68:7, 7:67, 7:64) | detalhes | 29.06.2022 |
| 1/64-finals | Taberner C. | Opelka R. | 0:3 (65:7, 4:6, 4:6) | detalhes | 28.06.2022 |
United Kingdom: Eastbourne - Singles - Main |
| 1/16-finals | Cressy M. | Opelka R. | 2:0 (6:3, 6:1) | detalhes | 20.06.2022 |
United Kingdom: London - Singles - Main |
| 1/16-finals | Opelka R. | De Minaur A. | 0:2 (4:6, 4:6) | detalhes | 13.06.2022 |
France: French Open - Singles - Main |
| 1/64-finals | Krajinovic F. | Opelka R. | 3:0 (7:65, 6:2, 6:3) | detalhes | 23.05.2022 |
Switzerland: Geneva - Singles - Main |
| Semi-finals | Opelka R. | Ruud C. | 0:2 (62:7, 5:7) | detalhes | 20.05.2022 |
| Quarter-finals | Griekspoor T. | Opelka R. | 1:2 (4:6, 6:3, 3:6) | detalhes | 19.05.2022 |